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Histology confirmed increased angiogenesis, greater fibroblast density, and improved collagen organization

Overall, the downregulated genes were enriched in GO terms related to muscle contraction, actin filament-based process, cation transport, cytoskeleton organization, smooth muscle contraction, extracellular matrix assembly and aorta development processes critical for maintaining vascular wall structure and function[45,46,47]

These cytokines drive chronic neuroinflammation, exacerbating microglial activation and neuronal loss and creating a vicious cycle of inflammation and neurodegeneration in PD

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